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OCR: with Patients who cease pubertal progression ertal GnRH agonist therapy resume their pul progression after cessation of therapy. It o is shown appropriate to use GnRH in a patient w. berty that to have progressive central precocious causes advancing bone age and physical d development, or in girls who have start premature menstrual periods. erone Medroxyprogesterone acetate and cypro ral acetate were used in the past to treat cen used since precocious puberty but have rarely been the advent of GnRH agonist therapy.